PDRN Is the Skincare Ingredient Everyone’s Talking About

Korean skincare has long set the pace for the global beauty scene. From innovative textures to cult routines, it continues to shape what ends up on our top shelf. The latest ingredient catching everyone’s eye? PDRN.

What Is PDRN?

PDRN, short for polydeoxyribonucleotide, is a DNA fragment usually sourced from salmon. When injected, it stimulates fibroblasts, the cells responsible for collagen production. Since collagen is the secret sauce for firm, smooth, and resilient skin, you can see why this one’s getting so much buzz. Korean dermatologists have been using PDRN injectables since 2014, with Rejuran leading the pack in pro treatments.

How PDRN Supports Your Skin

Most research so far focuses on PDRN in injectable form, but that hasn’t stopped skincare brands from adding it to creams and serums. While more studies are needed to confirm its full effects topically, early adopters are already seeing calmer, more hydrated, and healthier-looking skin.

Thanks to its regenerative powers, PDRN can support the skin’s natural healing process. It’s especially helpful after treatments like microneedling, lasers, or peels. Even without an in-office boost, it’s known to improve elasticity and texture over time, making skin more resilient against sun, stress, and inflammation.

Is PDRN Right for Your Skin?

PDRN is generally safe for all skin types, even sensitive skin. But since it’s often derived from marine sources, it’s not recommended if you have a seafood allergy. If that’s the case, look for plant-based alternatives made with ingredients like ginseng or green tea.

Struggling with dryness, sensitivity, or a compromised barrier? PDRN might just be the reset your skin’s been waiting for.